产品名称
SSTR4 Rabbit Polyclonal Antibody
别名
SSTR4; Somatostatin receptor type 4; SS-4-R; SS4-R; SS4R
蛋白名称
Somatostatin receptor type 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6754
Human Swissprot No.
P31391
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P31391/entry
Mouse Swissprot No.
P49660
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P49660
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25555
Rat Swissprot Link
http://www.uniprot.org/uniprot/P30937
免疫原
The antiserum was produced against synthesized peptide derived from human SSTR4. AA range:155-204
特异性
SSTR4 Polyclonal Antibody detects endogenous levels of SSTR4 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008],
组织表达
Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Specifically expressed in fetal and adult brain, lung tissue, stomach, and in lesser quantities in the kidney, pituitary and adrenals.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
