产品名称
SSTR1 Rabbit Polyclonal Antibody
别名
SSTR1; Somatostatin receptor type 1; SS-1-R; SS1-R; SS1R; SRIF-2
蛋白名称
Somatostatin receptor type 1
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6751
Human Swissprot No.
P30872
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30872/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20605
Mouse Swissprot No.
P30873
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P30873
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25033
Rat Swissprot Link
http://www.uniprot.org/uniprot/P28646
免疫原
The antiserum was produced against synthesized peptide derived from human SSTR1. AA range:9-58
特异性
SSTR1 Polyclonal Antibody detects endogenous levels of SSTR1 protein.
稀释度
WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012],
组织表达
Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Neuroactive ligand-receptor interaction;
功能
function:Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:Interacts with SKB1.,tissue specificity:Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
