产品名称
SSH3 Rabbit Polyclonal Antibody
别名
SSH3; SSH3L; Protein phosphatase Slingshot homolog 3; SSH-like protein 3; SSH-3L; hSSH-3L
蛋白名称
Protein phosphatase Slingshot homolog 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54961
Human Swissprot No.
Q8TE77
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TE77/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245857
Mouse Swissprot No.
Q8K330
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K330
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=365396
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5XIS1
免疫原
The antiserum was produced against synthesized peptide derived from human SSH3. AA range:357-406
特异性
SSH3 Polyclonal Antibody detects endogenous levels of SSH3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008],
组织表达
Cerebellum,Epithelium,Ovarian carcinoma,Uterus,
细胞定位
Cytoplasm, cytoskeleton . Nucleus .
信号通路
Regulates Actin and Cytoskeleton;
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly.,miscellaneous:Tyrosine phosphatase activity has not been demonstrated for this protein to date.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein-tyrosine phosphatase family.,similarity:Contains 1 tyrosine-protein phosphatase domain.,subunit:Does not bind to, or colocalize with, filamentous actin.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
