产品名称
SSBP1 Rabbit Polyclonal Antibody
别名
SSBP1; SSBP; Single-stranded DNA-binding protein; mitochondrial; Mt-SSB; MtSSB; PWP1-interacting protein 17
蛋白名称
Single-stranded DNA-binding protein mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6742
Human Swissprot No.
Q04837
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q04837/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=381760
Mouse Swissprot No.
Q9CYR0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CYR0
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54304
Rat Swissprot Link
http://www.uniprot.org/uniprot/P28042
免疫原
The antiserum was produced against synthesized peptide derived from human MtSSB. AA range:99-148
特异性
SSBP1 Polyclonal Antibody detects endogenous levels of SSBP1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010],
组织表达
Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level).
细胞定位
Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .
信号通路
DNA replication;Mismatch repair;Homologous recombination;
功能
function:This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 SSB domain.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
