产品名称
SR-6 Rabbit Polyclonal Antibody
别名
HTR6; 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6
蛋白名称
5-hydroxytryptamine receptor 6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3362
Human Swissprot No.
P50406
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P50406/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15565
Mouse Swissprot No.
Q9R1C8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R1C8
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64354
Rat Swissprot Link
http://www.uniprot.org/uniprot/P31388
免疫原
The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270
特异性
SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013],
组织表达
Expressed in several human brain regions, most prominently in the caudate nucleus.
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Calcium;Neuroactive ligand-receptor interaction;
功能
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
