产品名称
SR-1B Rabbit Polyclonal Antibody
别名
HTR1B; HTR1DB; 5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT1B; S12; Serotonin 1D beta receptor; 5-HT-1D-beta; Serotonin receptor 1B
蛋白名称
5-hydroxytryptamine receptor 1B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3351
Human Swissprot No.
P28222
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P28222/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15551
Mouse Swissprot No.
P28334
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P28334
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25075
Rat Swissprot Link
http://www.uniprot.org/uniprot/P28564
免疫原
The antiserum was produced against synthesized peptide derived from human 5-HT-1B. AA range:201-250
特异性
SR-1B Polyclonal Antibody detects endogenous levels of SR-1B protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015],
组织表达
Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen.
细胞定位
Cell membrane ; Multi-pass membrane protein .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,PTM:Palmitoylated.,PTM:Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
