产品名称
SR-1A Rabbit Polyclonal Antibody
别名
HTR1A; ADRB2RL1; ADRBRL1; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A
蛋白名称
5-hydroxytryptamine receptor 1A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3350
Human Swissprot No.
P08908
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08908/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=15550
Mouse Swissprot No.
Q64264
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64264
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24473
Rat Swissprot Link
http://www.uniprot.org/uniprot/P19327
免疫原
The antiserum was produced against synthesized peptide derived from human 5-HT-1A. AA range:291-340
特异性
SR-1A Polyclonal Antibody detects endogenous levels of SR-1A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012],
组织表达
Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.
细胞定位
Cell membrane ; Multi-pass membrane protein . Cell projection, dendrite .
信号通路
Neuroactive ligand-receptor interaction;
功能
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
