产品名称
SPZ1 Rabbit Polyclonal Antibody
别名
SPZ1; TSP1; Spermatogenic leucine zipper protein 1; Testis-specific protein 1; Testis-specific protein NYD-TSP1
蛋白名称
Spermatogenic leucine zipper protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84654
Human Swissprot No.
Q9BXG8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BXG8/entry
Mouse Swissprot No.
Q99MY0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99MY0
免疫原
The antiserum was produced against synthesized peptide derived from human SPZ1. AA range:111-160
特异性
SPZ1 Polyclonal Antibody detects endogenous levels of SPZ1 protein.
稀释度
WB 1:500-2000 IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011],
组织表达
Specifically and strongly expressed in the testis. Expressed in several tumor cell lines.
细胞定位
Cytoplasm . Nucleus .
功能
function:Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis.,PTM:Phosphorylated by ERK1 and ERK2.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Interacts with PPP1CC isoform gamma-2.,tissue specificity:Specifically and strongly expressed in the testis. Expressed in several tumor cell lines.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
