产品名称
SPAK Rabbit Polyclonal Antibody
别名
STK39; SPAK; STE20/SPS1-related proline-alanine-rich protein kinase; Ste-20-related kinase; DCHT; Serine/threonine-protein kinase 39
蛋白名称
STE20/SPS1-related proline-alanine-rich protein kinase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27347
Human Swissprot No.
Q9UEW8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UEW8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=53416
Mouse Swissprot No.
Q9Z1W9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z1W9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54348
Rat Swissprot Link
http://www.uniprot.org/uniprot/O88506
免疫原
The antiserum was produced against synthesized peptide derived from human STK39. AA range:277-326
特异性
SPAK Polyclonal Antibody detects endogenous levels of SPAK protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq, Jul 2008],
组织表达
Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.
细胞定位
Cytoplasm . Nucleus . Nucleus when caspase-cleaved. .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.,function:May act as a mediator of stress-activated signals.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Nucleus when caspase-cleaved.,tissue specificity:Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
