产品名称
Sp3/4 Rabbit Polyclonal Antibody
别名
SP3; Transcription factor Sp3; SPR-2; SP4; Transcription factor Sp4; SPR-1
蛋白名称
Transcription factor Sp3/4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6670
Human Swissprot No.
Q02447/Q02446
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q02447/entry
Mouse Gene ID
20687/20688
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20687
免疫原
The antiserum was produced against synthesized peptide derived from human SP3/4. AA range:671-720
特异性
Sp3/4 Polyclonal Antibody detects endogenous levels of Sp3/4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted. A related pseudogene has been identified on chromosome 13. [provided by RefSeq, Feb 2010],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus. Nucleus, PML body. Localizes to the nuclear periphery and in nuclear dots when sumoylated. Some localization in PML nuclear bodies.
功能
function:Transcriptional factor that can act as an activator or repressor, probably in a isoform-specific manner. Binds to GT and GC boxes promoters elements.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
