产品名称
Sox-6 Rabbit Polyclonal Antibody
别名
SOX6; Transcription factor SOX-6
蛋白名称
Transcription factor SOX-6
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55553
Human Swissprot No.
P35712
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P35712/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20679
Mouse Swissprot No.
P40645
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P40645
免疫原
The antiserum was produced against synthesized peptide derived from human SOX6. AA range:10-59
特异性
Sox-6 Polyclonal Antibody detects endogenous levels of Sox-6 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
SRY-box 6(SOX6) Homo sapiens This gene encodes a member of the D subfamily of sex determining region y-related transcription factors that are characterized by a conserved DNA-binding domain termed the high mobility group box and by their ability to bind the minor groove of DNA. The encoded protein is a transcriptional activator that is required for normal development of the central nervous system, chondrogenesis and maintenance of cardiac and skeletal muscle cells. The encoded protein interacts with other family members to cooperatively activate gene expression. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009],
组织表达
Expressed in a wide variety of tissues, most abundantly in skeletal musclen.
细胞定位
Nucleus . Cytoplasm .
功能
function:Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation.,PTM:Sumoylation inhibits the transcriptional activity.,similarity:Contains 1 HMG box DNA-binding domain.,subunit:Interacts with DAZAP2.,tissue specificity:Expressed in a wide variety of tissues, most abundantly in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
