BD-PT4363

SOCS-2 Rabbit Polyclonal Antibody

SOCS2; CIS2; SSI2; STATI2; Suppressor of cytokine signaling 2; SOCS-2; Cytokine-inducible SH2 protein 2; CIS-2; STAT-induced STAT inhibitor 2; SSI-2

常规抗体

SOCS2

Suppressor of cytokine signaling 2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

8835

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8835

O14508

http://www.uniprot.org/uniprotkb/O14508/entry

216233

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=216233

O35717

http://www.uniprot.org/uniprot/O35717

84607

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84607

O88582

http://www.uniprot.org/uniprot/O88582

The antiserum was produced against synthesized peptide derived from human SOCS-2. AA range:18-67

SOCS-2 Polyclonal Antibody detects endogenous levels of SOCS-2 protein.

WB 1:500-2000;IHC-p 1:50-300

22kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has

High expression in heart, placenta, lung, kidney and prostate. Predominantly expressed in pulmonary epithelia cells, specifically type II pneumocytes.

cytoplasm,cytosol,

Jak_STAT;Insulin_Receptor;Type II diabetes mellitus;

domain:The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.,function:SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,induction:By a subset of cytokines, including erythropoietin and granulocyte-macrophage colony stimulating factor (GM-CSF).,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SOCS box domain.,subunit:Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex.,tissue specificity:High expression in heart, placenta, lung, kidney and prostate.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.