产品名称
Socius Rabbit Polyclonal Antibody
别名
UBXN11; SOC; UBXD5; PP2243; UBX domain-containing protein 11; Colorectal tumor-associated antigen COA-1; Socius; UBX domain-containing protein 5
蛋白名称
UBX domain-containing protein 11
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=91544
Human Swissprot No.
Q5T124
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5T124/entry
Mouse Swissprot No.
Q9D572
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D572
免疫原
The antiserum was produced against synthesized peptide derived from human UBXD5. AA range:131-180
特异性
Socius Polyclonal Antibody detects endogenous levels of Socius protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with a divergent C-terminal UBX domain. The homologous protein in the rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins through their G-alpha subunits and promotes Rho GTPase activation. It is proposed to serve a bidirectional role in the promotion and inhibition of Rho activity through upstream signaling pathways. The 3' coding sequence of this gene contains a polymoprhic region of 24 nt tandem repeats. Several transcripts containing between 1.5 and five repeat units have been reported. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
组织表达
Colon cancer,Small intestine,Synovium,Testis,
细胞定位
Cytoplasm, cytoskeleton .
功能
function:May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13.,polymorphism:The number of repeats is polymorphic and varies from 1 to 4.,similarity:Contains 1 SEP domain.,similarity:Contains 1 UBX domain.,subunit:Interacts with GNA12, GNA13, RND1, RND2 AND RND3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
