产品名称
Snk Rabbit Polyclonal Antibody
别名
PLK2; SNK; Serine/threonine-protein kinase PLK2; Polo-like kinase 2; PLK-2; hPlk2; Serine/threonine-protein kinase SNK; hSNK; Serum-inducible kinase
蛋白名称
Serine/threonine-protein kinase PLK2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10769
Human Swissprot No.
Q9NYY3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NYY3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20620
Mouse Swissprot No.
P53351
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P53351
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83722
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9R012
免疫原
The antiserum was produced against synthesized peptide derived from human PLK2. AA range:291-340
特异性
Snk Polyclonal Antibody detects endogenous levels of Snk protein.
稀释度
WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011],
组织表达
Expressed at higher level in the fetal lung, kidney, spleen and heart.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, dendrite . Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase.
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:May play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 POLO box domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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