产品名称
SMUG1 Rabbit Polyclonal Antibody
别名
SMUG1; Single-strand selective monofunctional uracil DNA glycosylase
蛋白名称
Single-strand selective monofunctional uracil DNA glycosylase
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23583
Human Swissprot No.
Q53HV7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q53HV7/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71726
Mouse Swissprot No.
Q6P5C5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6P5C5
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315344
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q811Q1
免疫原
The antiserum was produced against synthesized peptide derived from human SMUG1. AA range:91-140
特异性
SMUG1 Polyclonal Antibody detects endogenous levels of SMUG1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that participates in base excision repair by removing uracil from single- and double-stranded DNA. Many alternatively spliced transcript variants exist for this gene; the full-length nature is known for some but not all of the variants. [provided by RefSeq, Aug 2011],
组织表达
Adipose tissue,Brain,Liver,Muscle,Ovary,Ute
信号通路
Base excision repair;
功能
function:Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
