产品名称
Smo Rabbit Polyclonal Antibody
别名
SMO; SMOH; Smoothened homolog; SMO; Protein Gx
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6608
Human Swissprot No.
Q99835
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99835/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=319757
Mouse Swissprot No.
P56726
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56726
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25273
Rat Swissprot Link
http://www.uniprot.org/uniprot/P97698
免疫原
The antiserum was produced against synthesized peptide derived from human SMO. AA range:68-117
特异性
Smo Polyclonal Antibody detects endogenous levels of Smo protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010],
组织表达
Brain,Embryonic lung,Synovial membrane,
细胞定位
Membrane ; Multi-pass membrane protein . Cell projection, cilium .
信号通路
Hedgehog;Pathways in cancer;Basal cell carcinoma;
功能
disease:Defects in SMO are involved in basal cell carcinoma (BCC).,function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
