产品名称
SMG7 Rabbit Polyclonal Antibody
别名
SMG7; C1orf16; EST1C; KIAA0250; Protein SMG7; EST1-like protein C; SMG-7 homolog; hSMG-7
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9887
Human Swissprot No.
Q92540
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92540/entry
Mouse Swissprot No.
Q5RJH6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5RJH6
免疫原
The antiserum was produced against synthesized peptide derived from human SMG7. AA range:521-570
特异性
SMG7 Polyclonal Antibody detects endogenous levels of SMG7 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
SMG7, nonsense mediated mRNA decay factor(SMG7) Homo sapiens This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011],
组织表达
Bone marrow,Brain,Epithelium,Testis,
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. .
功能
function:Plays a role in nonsense-mediated mRNA decay. Recruits RENT1 to cytoplasmic mRNA decay bodies.,similarity:Contains 2 TPR repeats.,subcellular location:Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.,subunit:Part of a complex that contains SMG5, SMG7, PP2AC, a short isoform of UPF3A (isoform UPF3AS, but not isoform UPF3AL) and phosphorylated RENT1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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