BD-PT4322

SLU7 Rabbit Polyclonal Antibody

SLU7; Pre-mRNA-splicing factor SLU7; hSlu7

常规抗体

SLU7

Pre-mRNA-splicing factor SLU7

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10569

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10569

O95391

http://www.uniprot.org/uniprotkb/O95391/entry

193116

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=193116

Q8BHJ9

http://www.uniprot.org/uniprot/Q8BHJ9

303057

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=303057

Q80ZG5

http://www.uniprot.org/uniprot/Q80ZG5

The antiserum was produced against synthesized peptide derived from human SLU7. AA range:113-162

SLU7 Polyclonal Antibody detects endogenous levels of SLU7 protein.

WB 1:500-2000;IHC-p 1:50-300

65kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq, Jul 2008],

Colon,Epithelium,Eye,

Nucleus . Nucleus speckle . Cytoplasm . Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. .

Spliceosome;

domain:The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.,function:Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.,similarity:Belongs to the SLU7 family.,similarity:Contains 1 CCHC-type zinc finger.,subcellular location:Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing.,subunit:Component of late spliceosomal complexes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.