产品名称
SLC4A8/10 Rabbit Polyclonal Antibody
别名
SLC4A8; KIAA0739; NBC; NBC3; NDCBE1; Electroneutral sodium bicarbonate exchanger 1; Electroneutral Na(+)-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3; SLC4A10; NCBE; Sodium-driven chloride bicarbonate exchanger; Solute
蛋白名称
Electroneutral sodium bicarbonate exchanger 1/Sodium-driven chloride bicarbonate exchanger
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57282
Human Swissprot No.
Q2Y0W8/Q6U841
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q2Y0W8/entry
Mouse Gene ID
59033/94229
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59033
Rat Gene ID
315311/295645
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315311
Rat Swissprot No.
Q6RVG2/Q80ZA5
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6RVG2
免疫原
The antiserum was produced against synthesized peptide derived from human SLC4A8/10. AA range:411-460
特异性
SLC4A8/10 Polyclonal Antibody detects endogenous levels of SLC4A8/10 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],
组织表达
Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.
细胞定位
Membrane ; Multi-pass membrane protein .
功能
function:Mediates electroneutral sodium- and carbonate-dependent choride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity.,miscellaneous:Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anionic channels and transporters).,similarity:Belongs to the anion exchanger (TC 2.A.31) family.,tissue specificity:Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
