产品名称
Skp1 p19 Rabbit Polyclonal Antibody
别名
SKP1; EMC19; OCP2; SKP1A; TCEB1L; S-phase kinase-associated protein 1; Cyclin-A/CDK2-associated protein p19; Organ of Corti protein 2; OCP-2; Organ of Corti protein II; OCP-II; RNA polymerase II elongation factor-like protein; SIII; Transcr
蛋白名称
S-phase kinase-associated protein 1
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6500
Human Swissprot No.
P63208
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P63208/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=21402
Mouse Swissprot No.
Q9WTX5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WTX5
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=287280
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6PEC4
免疫原
The antiserum was produced against synthesized peptide derived from human SKP1A/p19. AA range:41-90
特异性
Skp1 p19 Polyclonal Antibody detects endogenous levels of Skp1 p19 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008],
组织表达
Erythrocyte,Inner ear,Lung,Skin,Uterus,
细胞定位
nucleus,nucleoplasm,cytoplasm,centrosome,cytosol,SCF ubiquitin ligase complex,Cul7-RING ubiquitin ligase complex,PcG protein complex,extracellular exosome,
信号通路
Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;Oocyte meiosis;Ubiquitin mediated proteolysis;WNT;WNT-T CELLTGF-beta;
功能
function:Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the SKP1 family.,subunit:Interacts directly with CUL1 and F-box proteins, such as BTRC and SKP2, in the SCF complex. Interacts with the cyclin A/CDK2 complex. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
