产品名称
Six3/6 Rabbit Polyclonal Antibody
别名
SIX6; OPTX2; SIX9; Homeobox protein SIX6; Homeodomain protein OPTX2; Optic homeobox 2; Sine oculis homeobox homolog 6
蛋白名称
Homeobox protein SIX6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4990
Human Swissprot No.
O95475
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95475/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20476
Mouse Swissprot No.
Q9QZ28
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QZ28
免疫原
The antiserum was produced against synthesized peptide derived from human SIX6. AA range:121-170
特异性
Six3/6 Polyclonal Antibody detects endogenous levels of Six3/6 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008],
组织表达
Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.
功能
disease:Defects in SIX6 are the cause of microphthalmia isolated with cataract type 2 (MCOPCT2) [MIM:212550]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataractand other abnormalities like cataract may also be present.,function:May be involved in eye development.,similarity:Belongs to the SIX/Sine oculis homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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