产品名称
Six1 Rabbit Polyclonal Antibody
别名
SIX1; Homeobox protein SIX1; Sine oculis homeobox homolog 1
蛋白名称
Homeobox protein SIX1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6495
Human Swissprot No.
Q15475
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15475/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20471
Mouse Swissprot No.
Q62231
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62231
免疫原
The antiserum was produced against synthesized peptide derived from human SIX1. AA range:111-160
特异性
Six1 Polyclonal Antibody detects endogenous levels of Six1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). [provided by RefSeq, Jul 2008],
组织表达
Specifically expressed in skeletal muscle.
细胞定位
Nucleus . Cytoplasm.
功能
disease:Defects in SIX1 are the cause of autosomal dominant deafness type 23 (DFNA23) [MIM:605192].,disease:Defects in SIX1 are the cause of branchiootic syndrome type 3 (BOS3) [MIM:608389]. Urinary tract malformations constitute the most frequent cause of chronic renal failure in the first two decades of life. Branchio-oto-renal syndrome (BOR) is an autosomal dominant developmental disorder of kidney and urinary tract malformations with hearing loss. The major feature of BOR is hearing loss (93% of patients), which can be conductive, sensorineural, or both and varies in age of onset.,function:May be involved in limb tendon and ligament development.,similarity:Belongs to the SIX/Sine oculis homeobox family.,similarity:Contains 1 homeobox DNA-binding domain.,tissue specificity:Specifically expressed in skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
