产品名称
SGLT-2 Rabbit Polyclonal Antibody
别名
SLC5A2; SGLT2; Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2
蛋白名称
Sodium/glucose cotransporter 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6524
Human Swissprot No.
P31639
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P31639/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=246787
Mouse Swissprot No.
Q923I7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q923I7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64522
Rat Swissprot Link
http://www.uniprot.org/uniprot/P53792
免疫原
The antiserum was produced against synthesized peptide derived from human SLC5A2. AA range:101-150
特异性
SGLT-2 Polyclonal Antibody detects endogenous levels of SGLT-2 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015],
细胞定位
Apical cell membrane ; Multi-pass membrane protein .
功能
disease:Defects in SLC5A2 are the cause of renal glucosuria (GLYS1) [MIM:233100]. GLYS1 is an autosomal recessive disorder characterized by a normal fasting serum glucose concentration and persistent isolated glucosuria, with a normal glucose tolerance test.,function:Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.,function:Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.,similarity:Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
