产品名称
SGLT-1 Rabbit Polyclonal Antibody
别名
SLC5A1; NAGT; SGLT1; Sodium/glucose cotransporter 1; Na(+)/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1
蛋白名称
Sodium/glucose cotransporter 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6523
Human Swissprot No.
P13866
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P13866/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20537
Mouse Swissprot No.
Q8C3K6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8C3K6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25552
Rat Swissprot Link
http://www.uniprot.org/uniprot/P53790
免疫原
The antiserum was produced against synthesized peptide derived from human SGLT-1. AA range:525-574
特异性
SGLT-1 Polyclonal Antibody detects endogenous levels of SGLT-1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
组织表达
Expressed in intestine (PubMed:2490366). Expressed in endometrial cells (PubMed:28974690).
细胞定位
Apical cell membrane ; Multi-pass membrane protein .
功能
disease:Defects in SLC5A1 are the cause of congenital glucose/galactose malabsorption (GGM) [MIM:606824]. GGM is an intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet.,function:Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.,PTM:N-glycosylation is not necessary for the cotransporter function.,similarity:Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.,tissue specificity:Expressed mainly in intestine and kidney.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
