产品名称
SgK269 Rabbit Polyclonal Antibody
别名
PEAK1; KIAA2002; Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269
蛋白名称
Pseudopodium-enriched atypical kinase 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79834
Human Swissprot No.
Q9H792
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H792/entry
Mouse Swissprot No.
Q69Z38
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q69Z38
免疫原
The antiserum was produced against synthesized peptide derived from human SGK269. AA range:111-160
特异性
SgK269 Polyclonal Antibody detects endogenous levels of SgK269 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014],
组织表达
Brain,Epithelium,Lung,Mesangial cell,Smooth muscle,Spleen,
细胞定位
Cytoplasm, cytoskeleton . Cell junction, focal adhesion . Colocalizes with F-actin in serum-rich medium (PubMed:20534451). Actin colocalization is reduced during serum starvation (PubMed:20534451). .
功能
catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
