BD-PT4253

SERCA1 Rabbit Polyclonal Antibody

ATP2A1; Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; SERCA1; SR Ca(2+)-ATPase 1; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type; fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) AT

常规抗体

ATP2A1

Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

WB

Human,Mouse,Rat,Salamander,Pig

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

487

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=487

O14983

http://www.uniprot.org/uniprotkb/O14983/entry

11937

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11937

Q8R429

http://www.uniprot.org/uniprot/Q8R429

116601

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116601

Q64578

http://www.uniprot.org/uniprot/Q64578

The antiserum was produced against synthesized peptide derived from human ATP2A1. AA range:548-597

SERCA1 Polyclonal Antibody detects endogenous levels of SERCA1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

100kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013],

Skeletal muscle, fast twitch muscle (type II) fibers.

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .

Calcium;Alzheimer's disease;

catalytic activity:ATP + H(2)O + Ca(2+)(Cis) = ADP + phosphate + Ca(2+)(Trans).,developmental stage:Isoform SERCA1A accounts for more than 99% of SERCA1 isoforms expressed in adult, while isoform SERCA1B predominates in neo-natal fibers.,disease:Defects in ATP2A1 are the cause of Brody disease (BD) [MIM:601003]. BD is an autosomal recessive myopathy characterized by increasing impairment of relaxation of fast twist skeletal muscle during exercise.,enzyme regulation:Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN.,function:This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.,induction:Increased contractile activity leads to decrease SERCA1 expression, while decreased contractile activity leads to increase of SERCA1 expression.,similarity:Belongs to the cation transport ATPase (P-type) family.,similarity:Belongs to the cation transport ATPase (P-type) family. Type IIA subfamily.,subunit:Associated with sarcolipin (SLN) and phospholamban (PLN).,tissue specificity:Skeletal muscle, fast twitch muscle (type II) fibers.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.