产品名称
Septin 6 Rabbit Polyclonal Antibody
别名
SEPT6; KIAA0128; SEP2; Septin-6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23157
Human Swissprot No.
Q14141
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q14141/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56526
Mouse Swissprot No.
Q9R1T4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R1T4
免疫原
The antiserum was produced against synthesized peptide derived from human SEPT6. AA range:223-272
特异性
Septin 6 Polyclonal Antibody detects endogenous levels of Septin 6 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
septin 6(SEPT6) Homo sapiens This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Cleavage furrow . Midbody . Cell projection, cilium, flagellum . In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. Found in the sperm annulus (PubMed:25588830). .
功能
function:Involved in cytokinesis .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the septin family.,subunit:Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments. Interacts with SEPT12. Interaction with SEPT12 alters filament structure.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
