产品名称
Septin 5 Rabbit Polyclonal Antibody
别名
SEPT5; PNUTL1; Septin-5; Cell division control-related protein 1; CDCrel-1; Peanut-like protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5413
Human Swissprot No.
Q99719
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99719/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18951
Mouse Swissprot No.
Q9Z2Q6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z2Q6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116728
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9JJM9
免疫原
Synthesized peptide derived from Septin 5 . at AA range: 180-260
特异性
Septin 5 Polyclonal Antibody detects endogenous levels of Septin 5 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
septin 5(SEPT5) Homo sapiens This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010],
组织表达
Expressed at high levels in the CNS, as well as in heart and platelets (at protein level).
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . In platelets, found in areas surrounding alpha-granules.
信号通路
Parkinson's disease;
功能
function:Involved in cytokinesis .,similarity:Belongs to the septin family.,subunit:May assemble into a multicomponent structure.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
