产品名称
Septin 2 Rabbit Polyclonal Antibody
别名
SEPT2; DIFF6; KIAA0158; NEDD5; Septin-2; Neural precursor cell expressed developmentally down-regulated protein 5; NEDD-5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4735
Human Swissprot No.
Q15019
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15019/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18000
Mouse Swissprot No.
P42208
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P42208
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117515
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q91Y81
免疫原
The antiserum was produced against synthesized peptide derived from human SEPT2. AA range:103-152
特异性
Septin 2 Polyclonal Antibody detects endogenous levels of Septin 2 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Required for normal progress through mitosis. Involved in cytokinesis.,similarity:Belongs to the septin family.,subcellular location:Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localised to fibrous or granular structures, depending on the growth state of the cell.,subunit:Monomer, and homodimer. Nucleotide binding promotes dimerization. Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments.,
组织表达
Widely expressed. Up-regulated in liver cancer.
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, spindle . Chromosome, centromere, kinetochore . Cleavage furrow . Midbody . Cytoplasm, cell cortex . Cell projection, cilium membrane . Cell projection, cilium, flagellum . In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. Found in the sperm annulus (PubMed:25588830). .
功能
function:Required for normal progress through mitosis. Involved in cytokinesis.,similarity:Belongs to the septin family.,subcellular location:Accumulates near the contractile ring from anaphase through telophase, and finally condenses into the midbody. In interphase and postmitotic cells, localised to fibrous or granular structures, depending on the growth state of the cell.,subunit:Monomer, and homodimer. Nucleotide binding promotes dimerization. Heterohexamer composed of two heterotrimers containing one copy each of SEPT2, SEPT6 and SEPT7. The asymmetrical heterotrimers associate head-to-head to form a hexameric unit that assembles into filaments.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
