产品名称
SENP5 Rabbit Polyclonal Antibody
别名
SENP5; FKSG45; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5
蛋白名称
Sentrin-specific protease 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=205564
Human Swissprot No.
Q96HI0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96HI0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=320213
Mouse Swissprot No.
Q6NXL6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6NXL6
免疫原
The antiserum was produced against synthesized peptide derived from human SENP5. AA range:651-700
特异性
SENP5 Polyclonal Antibody detects endogenous levels of SENP5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009],
细胞定位
Nucleus, nucleolus .
功能
function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.,similarity:Belongs to the peptidase C48 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
