产品名称
SENP2 Rabbit Polyclonal Antibody
别名
SENP2; KIAA1331; Sentrin-specific protease 2; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2
蛋白名称
Sentrin-specific protease 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59343
Human Swissprot No.
Q9HC62
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HC62/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75826
Mouse Swissprot No.
Q91ZX6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91ZX6
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78973
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9EQE1
免疫原
The antiserum was produced against synthesized peptide derived from human SENP2. AA range:481-530
特异性
SENP2 Polyclonal Antibody detects endogenous levels of SENP2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
SUMO1 (UBL1; MIM 601912) is a small ubiquitin-like protein that can be covalently conjugated to other proteins. SENP2 is one of a group of enzymes that process newly synthesized SUMO1 into the conjugatable form and catalyze the deconjugation of SUMO1-containing species.[supplied by OMIM, Apr 2004],
组织表达
Brain,Fetal brain,Melanoma,Teratocarcinoma,
细胞定位
Nucleus, nuclear pore complex . Nucleus membrane ; Peripheral membrane protein ; Nucleoplasmic side . Cytoplasm . Shuttles between cytoplasm and nucleus. .
功能
domain:The N-terminus is necessary and sufficient for nuclear envelope targeting.,function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.,PTM:Polyubiquitinated; which leads to proteasomal degradation.,similarity:Belongs to the peptidase C48 family.,subcellular location:Shuttles between cytoplasm and nucleus.,subunit:Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
