产品名称
SENP1 Rabbit Polyclonal Antibody
别名
SENP1; Sentrin-specific protease 1; Sentrin/SUMO-specific protease SENP1
蛋白名称
Sentrin-specific protease 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29843
Human Swissprot No.
Q9P0U3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9P0U3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=223870
Mouse Swissprot No.
P59110
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P59110
免疫原
The antiserum was produced against synthesized peptide derived from human SENP1. AA range:1-50
特异性
SENP1 Polyclonal Antibody detects endogenous levels of SENP1 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012],
组织表达
Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
细胞定位
Nucleus . Cytoplasm. Shuttles between cytoplasm and nucleus.
功能
function:Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1, which decreases its transcriptional repression activity.,similarity:Belongs to the peptidase C48 family.,subcellular location:Shuttles between cytoplasm and nucleus.,tissue specificity:Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
