BD-PT4235

SEMA4A Rabbit Polyclonal Antibody

SEMA4A; SEMAB; SEMB; Semaphorin-4A; Semaphorin-B; Sema B

常规抗体

SEMA4A

Semaphorin-4A

WB

Human,Mouse,Rat,Monkey

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

64218

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64218

Q9H3S1

http://www.uniprot.org/uniprotkb/Q9H3S1/entry

20351

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20351

Q62178

http://www.uniprot.org/uniprot/Q62178

The antiserum was produced against synthesized peptide derived from human SEMA4A. AA range:501-550

SEMA4A Polyclonal Antibody detects endogenous levels of SEMA4A protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

84kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identif

Colon,Mammary gland,Placenta,Salivary gland,Tongue,

Cell membrane ; Single-pass type I membrane protein .

Axon guidance;

disease:Defects in SEMA4A are the cause of cone-rod dystrophy type 10 (CORD10) [MIM:610283]. CORDs are inherited retinal dystrophies belonging to the group of pigmentary retinopathies. CORDs are characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa.,disease:Defects in SEMA4A are the cause of retinitis pigmentosa type 35 (RP35) [MIM:610282]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.,function:Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.,similarity:Belongs to the semaphorin family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 PSI domain.,similarity:Contains 1 Sema domain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.