产品名称
SEMA3F Rabbit Polyclonal Antibody
别名
SEMA3F; Semaphorin-3F; Sema III/F; Semaphorin IV; Sema IV
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6405
Human Swissprot No.
Q13275
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13275/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20350
Mouse Swissprot No.
O88632
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O88632
免疫原
The antiserum was produced against synthesized peptide derived from human SEMA3F. AA range:734-783
特异性
SEMA3F Polyclonal Antibody detects endogenous levels of SEMA3F protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the semaphorin III family of secreted signaling proteins that are involved in axon guidance during neuronal development. The encoded protein contains an N-terminal Sema domain, an immunoglobulin loop and a C-terminal basic domain. This gene is expressed by the endothelial cells where it was found to act in an autocrine fashion to induce apoptosis, inhibit cell proliferation and survival, and function as an anti-tumorigenic agent. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],
组织表达
Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.
功能
developmental stage:Detected as early as embryonic day 10.,function:May play a role in cell motility and cell adhesion.,similarity:Belongs to the semaphorin family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Sema domain.,tissue specificity:Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
