产品名称
Sck Rabbit Polyclonal Antibody
别名
SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2
蛋白名称
SHC-transforming protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25759
Human Swissprot No.
P98077
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P98077/entry
Mouse Swissprot No.
Q8BMC3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BMC3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=314612
Rat Swissprot Link
http://www.uniprot.org/uniprot/O70142
免疫原
The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310
特异性
Sck Polyclonal Antibody detects endogenous levels of Sck protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,
组织表达
Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.
细胞定位
intracellular,cytosol,plasma membrane,
信号通路
ErbB_HER;Chemokine;VEGF;Focal adhesion;Natural killer cell mediated cytotoxicity;Neurotrophin;Insulin_Receptor;Glioma;Chronic myeloid leukemia;
功能
domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
