产品名称
Scn4b Rabbit Polyclonal Antibody
别名
SCN4B; Sodium channel subunit beta-4
蛋白名称
Sodium channel subunit beta-4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6330
Human Swissprot No.
Q8IWT1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IWT1/entry
Mouse Swissprot No.
Q7M729
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7M729
免疫原
The antiserum was produced against synthesized peptide derived from human SCN4B. AA range:61-110
特异性
Scn4b Polyclonal Antibody detects endogenous levels of Scn4b protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009],
组织表达
Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
细胞定位
Cell membrane ; Single-pass type I membrane protein .
功能
disease:Defects in SCN4B are the cause of long QT syndrome type 10 (LQT10) [MIM:611819]. Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress. They can present with a sentinel event of sudden cardiac death in infancy.,function:Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.,PTM:Contains a number of interchain disulfide bonds with SCN2A.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,subunit:The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds. Associates with SCN2A.,tissue specificity:Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
