产品名称
AP-1 (Acetyl Lys271) Rabbit Polyclonal Antibody
别名
JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
蛋白名称
Transcription factor AP-1;jun;c-jun；AP-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3725
Human Swissprot No.
P05412
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P05412/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16476
Mouse Swissprot No.
P05627
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P05627
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24516
Rat Swissprot Link
http://www.uniprot.org/uniprot/P17325
免疫原
Synthesized acetyl-peptide derived from the Internal region of human AP-1 around the acetylation site of K271.
特异性
Acetyl-AP-1 (K271) Polyclonal Antibody detects endogenous levels of AP-1 protein only when acetylation at K271.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the developing and adult prostate and prostate cancer cells.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;WNT;WNT-T CELLFocal adhesion;Toll_Like;T_Cell_Receptor;B_Cell_Antigen;Neurotrophin;GnRH;Epithelial cell signaling in Helicobacter pylori infection;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;
功能
function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
