BD-PT4211

SAP 49 Rabbit Polyclonal Antibody

SF3B4; SAP49; Splicing factor 3B subunit 4; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SF3b50; Spliceosome-associated protein 49; SAP 49

常规抗体

SF3B4

Splicing factor 3B subunit 4

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

10262

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10262

Q15427

http://www.uniprot.org/uniprotkb/Q15427/entry

107701

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107701

Q8QZY9

http://www.uniprot.org/uniprot/Q8QZY9

295270

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=295270

Q6AYL5

http://www.uniprot.org/uniprot/Q6AYL5

The antiserum was produced against synthesized peptide derived from human SF3B4. AA range:61-110

SAP 49 Polyclonal Antibody detects endogenous levels of SAP 49 protein.

WB 1:500-2000

55kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008],

Ovarian carcinoma,Skin,Testis,Thymus,

Nucleus .

Spliceosome;

function:Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.,similarity:Belongs to the SF3B4 family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,subunit:Component of splicing factor SF3B which is composed of at least eight subunits; SF3B1/SAP155/SF3B155, SF3B2/SAP145/SF3B145, SF3B3/SAP130/SF3B130, SF3B4/SAP49/SF3B49, SF3B14A, PHF5A/SF3B14B, SF3B10 and SF3B125. SF3B associates with the splicing factor SF3A and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). SF3B4 interacts directly with SF3B2.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.