产品名称
S-100A10 Rabbit Polyclonal Antibody
别名
S100A10; ANX2LG; CAL1L; CLP11; Protein S100-A10; Calpactin I light chain; Calpactin-1 light chain; Cellular ligand of annexin II; S100 calcium-binding protein A10; p10 protein; p11
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6281
Human Swissprot No.
P60903
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P60903/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20194
Mouse Swissprot No.
P08207
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P08207
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81778
Rat Swissprot Link
http://www.uniprot.org/uniprot/P05943
免疫原
The antiserum was produced against synthesized peptide derived from human S-100A10. AA range:3-52
特异性
S-100A10 Polyclonal Antibody detects endogenous levels of S-100A10 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in exocytosis and endocytosis. [provided by RefSeq, Jul 2008],
细胞定位
integral component of membrane,extrinsic component of plasma membrane,membrane raft,extracellular exosome,
功能
function:Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase.,miscellaneous:Does not appear to bind calcium. Contains 2 ancestral calcium site related to EF-hand domains that have lost their ability to bind calcium.,similarity:Belongs to the S-100 family.,subunit:Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with SCN10A.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
