BD-PT4195-RXRγ Rabbit Polyclonal Antibody-现货抗体产品库武汉枢密脑科学技术有限公司

RXRγ Rabbit Polyclonal Antibody

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产品基本信息

产品货号

BD-PT4195

产品名称

RXRγ Rabbit Polyclonal Antibody

别名

RXRG; NR2B3; Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma

类别

常规抗体

基因名称

RXRG

蛋白名称

Retinoic acid receptor RXR-gamma

推荐应用

反应种属

Human,Mouse

浓度

1 mg/ml

存储缓冲液

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

Human Gene ID

6258

Human Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6258

Human Swissprot No.

P48443

Human Swissprot Link

http://www.uniprot.org/uniprotkb/P48443/entry

Mouse Gene ID

20183

Mouse Gene Link

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20183

Mouse Swissprot No.

P28705

Mouse Swissprot Link

http://www.uniprot.org/uniprot/P28705

免疫原

The antiserum was produced against synthesized peptide derived from human Retinoid X Receptor gamma. AA range:171-220

特异性

RXRγ Polyclonal Antibody detects endogenous levels of RXRγ protein.

稀释度

WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

预测分子量

50kD

运输及保存条件

-20°C/1 year

宿主

Polyclonal, Rabbit,IgG

背景介绍

retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],

组织表达

Expressed in aortic endothelial cells (at protein level).

细胞定位

Nucleus . Cytoplasm .

信号通路

PPAR;Adipocytokine;Pathways in cancer;Thyroid cancer;Small cell lung cancer;Non-small cell lung cancer;

功能

caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,

期货

现货

纯化

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunofluorescence analysis of HUVEC cells, using Retinoid X Receptor gamma Antibody. The picture on the right is blocked with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using Retinoid X Receptor gamma Antibody. The picture on the right is blocked with the synthesized peptide.

Western blot analysis of lysates from HepG2 cells, using Retinoid X Receptor gamma Antibody. The lane on the right is blocked with the synthesized peptide.

Western Blot analysis of various cells using RXRγ Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.

Western Blot analysis of HepG2 cells using RXRγ Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit （SC-003,Inventbiotech,MN,USA）.

Immunohistochemical analysis of paraffin-embedded Human lung cancer. Antibody was diluted at 1:100（4°,overnight）. High-pressure and temperature Tris-EDTA,pH8.0 was used for antigen retrieval.