产品名称
Rsk-4 Rabbit Polyclonal Antibody
别名
RPS6KA6; RSK4; Ribosomal protein S6 kinase alpha-6; S6K-alpha-6; 90 kDa ribosomal protein S6 kinase 6; p90-RSK 6; p90RSK6; Ribosomal S6 kinase 4; RSK-4; pp90RSK4
蛋白名称
Ribosomal protein S6 kinase alpha-6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27330
Human Swissprot No.
Q9UK32
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UK32/entry
Mouse Swissprot No.
Q7TPS0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TPS0
免疫原
The antiserum was produced against synthesized peptide derived from human S6K-alpha6. AA range:661-710
特异性
Rsk-4 Polyclonal Antibody detects endogenous levels of Rsk-4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
ribosomal protein S6 kinase A6(RPS6KA6) Homo sapiens This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010],
细胞定位
Cytoplasm, cytosol . Nucleus . Predominantly cytosolic.
信号通路
Insulin Receptor; Regulates Angiogenesis; mTOR; B Cell Receptor; AMPK
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-389, as part of the activation process.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
