产品名称
ERC2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.246% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/26059
Human Swissprot No.
O15083
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15083/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/238988
Mouse Swissprot No.
Q6PH08
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PH08
Rat Gene Link
https://www.uniprot.org/uniprot/259269
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K3M6
免疫原
Synthesized peptide derived from human ERC2 AA range: 368-418
特异性
This antibody detects endogenous levels of ERC2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that belongs to the Rab3-interacting molecule (RIM)-binding protein family. Members of this protein family form part of the cytomatrix at the active zone (CAZ) complex and function as regulators of neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015],
组织表达
Brain,Epithelium,PNS,
细胞定位
Cytoplasm . Cell junction, synapse . Cell junction, synapse, presynaptic active zone . Cytoplasm, cytoskeleton . In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). .
功能
function:Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,subcellular location:In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density.,subunit:Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
