BD-PT4165

ROR2 Rabbit Polyclonal Antibody

ROR2; NTRKR2; Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase; receptor-related 2

常规抗体

ROR2

Tyrosine-protein kinase transmembrane receptor ROR2

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

4920

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4920

Q01974

http://www.uniprot.org/uniprotkb/Q01974/entry

Q9Z138

http://www.uniprot.org/uniprot/Q9Z138

Synthesized peptide derived from ROR2 . at AA range: 450-530

ROR2 Polyclonal Antibody detects endogenous levels of ROR2 protein.

WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

110kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008],

Brain,

Cell membrane ; Single-pass type I membrane protein .

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,developmental stage:Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.,disease:Defects in ROR2 are a cause of brachydactyly type B1 (BDB1) [MIM:113000]. BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short but in addition the terminal phalanges are rudimentary or absent. Both fingers and toes are affected. The thumbs and big toes are usually deformed.,disease:Defects in ROR2 are a cause of recessive Robinow syndrome (RRS) [MIM:268310]. RRS is an autosomal disorder characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly and a dysmorphic facial appearance.,function:Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 protein kinase domain.,subunit:Homodimer; promotes osteogenesis. Binds YWHAB.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.