产品名称
RNF138 Rabbit Polyclonal Antibody
别名
RNF138; NARF; HSD-4; HSD4; E3 ubiquitin-protein ligase RNF138; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; hNARF; RING finger protein 138
蛋白名称
E3 ubiquitin-protein ligase RNF138
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51444
Human Swissprot No.
Q8WVD3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8WVD3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56515
Mouse Swissprot No.
Q9CQE0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9CQE0
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94196
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q99PD2
免疫原
The antiserum was produced against synthesized peptide derived from human RNF138. AA range:31-80
特异性
RNF138 Polyclonal Antibody detects endogenous levels of RNF138 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
ring finger protein 138(RNF138) Homo sapiens The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
组织表达
Placenta,Testis,Uterus,
细胞定位
Chromosome . Recruited at DNA damage sites (PubMed:26502055). Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057). .
功能
domain:The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.,function:E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with nlk.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
