BD-PT4148

M-RIP Rabbit Polyclonal Antibody

MPRIP; KIAA0864; MRIP; RHOIP3; Myosin phosphatase Rho-interacting protein; M-RIP; Rho-interacting protein 3; RIP3; p116Rip

常规抗体

MPRIP

Myosin phosphatase Rho-interacting protein

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

23164/23164

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23164

Q6WCQ1

http://www.uniprot.org/uniprotkb/Q6WCQ1/entry

26936

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26936

P97434

http://www.uniprot.org/uniprot/P97434

116504

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116504

Q9ERE6

http://www.uniprot.org/uniprot/Q9ERE6

Synthesized peptide derived from the Internal region of human M-RIP.

M-RIP Polyclonal Antibody detects endogenous levels of M-RIP protein.

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

115kD

-20°C/1 year

Polyclonal, Rabbit,IgG

function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Colocalizes with F-actin.,subunit:Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.,

Aorta,Brain,Epithelium,Lymph,Melanoma,Muscle,Ovary,Tongue,

Cytoplasm, cytoskeleton . Colocalizes with F-actin.

function:Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.,similarity:Contains 1 PH domain.,similarity:Contains 2 PH domains.,subcellular location:Colocalizes with F-actin.,subunit:Binds F-actin through its N-terminus (By similarity). Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.