产品名称
RIN3 Rabbit Polyclonal Antibody
别名
RIN3; Ras and Rab interactor 3; Ras interaction/interference protein 3
蛋白名称
Ras and Rab interactor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79890
Human Swissprot No.
Q8TB24
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TB24/entry
Mouse Swissprot No.
P59729
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P59729
免疫原
The antiserum was produced against synthesized peptide derived from human RIN3. AA range:391-440
特异性
RIN3 Polyclonal Antibody detects endogenous levels of RIN3 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
细胞定位
Cytoplasm . Cytoplasmic vesicle . Early endosome . Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. .
功能
caution:The region from Asp-168 to Pro-327 is deduced from the genomic sequence by similarity to the mouse sequence.,function:Potential Ras effector protein. May function as a guanine nucleotide exchange (GEF), by exchanging bound GDP for free GTP.,similarity:Belongs to the RIN (Ras interaction/interference) family.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 VPS9 domain.,subcellular location:Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles.,subunit:Interacts with RAB5B and BIN1.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
