产品名称
Ribosomal Protein S6 Rabbit Polyclonal Antibody
别名
RPS6; OK/SW-cl.2; 40S ribosomal protein S6; Phosphoprotein NP33
蛋白名称
40S ribosomal protein S6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6194
Human Swissprot No.
P62753
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P62753/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20104
Mouse Swissprot No.
P62754
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P62754
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=100911372
Rat Swissprot Link
http://www.uniprot.org/uniprot/P62755
免疫原
The antiserum was produced against synthesized peptide derived from human S6 Ribosomal Protein. AA range:191-240
特异性
Ribosomal Protein S6 Polyclonal Antibody detects endogenous levels of Ribosomal Protein S6 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed
组织表达
Brain,Colon,Colon adenocarcinoma,Epithelium,Muscle,Ovary,Pancreas,Placenta,Skin,Tes
细胞定位
nucleus,nucleoplasm,nucleolus,cytoplasm,cytosol,ribosome,polysome,small ribosomal subunit,membrane,cytosolic small ribosomal subunit,dendrite,intracellular ribonucleoprotein complex,cytoplasmic ribonucleoprotein granu
信号通路
Ribosome;mTOR;Insulin_Receptor;
功能
function:May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.,PTM:Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest.,similarity:Belongs to the ribosomal protein S6e family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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