产品名称
KIF5C Rabbit Polyclonal Antibody
别名
Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2)
基因名称
KIF5C KIAA0531 NKHC2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.247% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/3800
Human Swissprot No.
O60282
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60282/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16574
Mouse Swissprot No.
P28738
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P28738
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P56536
免疫原
Synthesized peptide derived from human KIF5C AA range: 119-169
特异性
This antibody detects endogenous levels of KIF5C at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts with protein kinase CK2. Mutations in this gene have been associated with complex cortical dysplasia with other brain malformations-2. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Jul 2015],
组织表达
Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.
细胞定位
Cytoplasm, cytoskeleton . Cell projection, dendrite . Abundant in distal regions of dendrites. .
功能
domain:Composed of three structural domains: a large globular N-terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.,function:Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport.,similarity:Belongs to the kinesin-like protein family.,similarity:Belongs to the kinesin-like protein family. Kinesin subfamily.,similarity:Contains 1 kinesin-motor domain.,subunit:Oligomer composed of two heavy chains and two light chains. Interacts with GRIP1 and KLC3.,tissue specificity:Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
