产品名称
RIAM Rabbit Polyclonal Antibody
别名
APBB1IP; PREL1; RARP1; RIAM; Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; APBB1-interacting protein 1; Proline-rich EVH1 ligand 1; PREL-1; Proline-rich protein 73; Rap1-GTP-interacting adapter molecule; R
蛋白名称
Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54518
Human Swissprot No.
Q7Z5R6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q7Z5R6/entry
Mouse Swissprot No.
Q8R5A3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8R5A3
免疫原
Synthesized peptide derived from RIAM . at AA range: 430-510
特异性
RIAM Polyclonal Antibody detects endogenous levels of RIAM protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
domain:The two Pro-rich regions are required for the suppression of AP1 transcription activity.,function:Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.,induction:Induced by all-trans-retinoic acid.,similarity:Belongs to the MRL family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,subcellular location:Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.,subunit:Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH.,tissue specificity:Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.,
组织表达
Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
细胞定位
Cell membrane ; Peripheral membrane protein . Cell projection, lamellipodium . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases (By similarity). .
功能
domain:The two Pro-rich regions are required for the suppression of AP1 transcription activity.,function:Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.,induction:Induced by all-trans-retinoic acid.,similarity:Belongs to the MRL family.,similarity:Contains 1 PH domain.,similarity:Contains 1 Ras-associating domain.,subcellular location:Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.,subunit:Interacts, through the N-terminal Pro-rich region, with the WW domain of APBB1. Interacts with RAP1A, PFN1, VASP and ENAH.,tissue specificity:Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
