BD-PT4087

Rhodopsin Rabbit Polyclonal Antibody

RHO; OPN2; Rhodopsin; Opsin-2

常规抗体

RHO

Rhodopsin

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

6010

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6010

P08100

http://www.uniprot.org/uniprotkb/P08100/entry

212541

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=212541

P15409

http://www.uniprot.org/uniprot/P15409

24717

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24717

P51489

http://www.uniprot.org/uniprot/P51489

The antiserum was produced against synthesized peptide derived from human Rhodopsin. AA range:299-348

Rhodopsin Polyclonal Antibody detects endogenous levels of Rhodopsin protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

42kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008],

Rod shaped photoreceptor cells which mediate vision in dim light.

Membrane ; Multi-pass membrane protein . Cell projection, cilium, photoreceptor outer segment . Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. .

Regulation of Microtubule Dynamics; Regulation of Actin Dynamics; SAPK_JNK; B_Cell_Antigen

disease:Defects in RHO are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000].,disease:Defects in RHO are the cause of congenital stationary night blindness autosomal dominant type 1 (CSNBAD1) [MIM:610445]; also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision.,disease:Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4) [MIM:180380]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant.,function:Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal.,online information:Retina International's Scientific Newsletter,online information:Rhodopsin entry,online information:Rhodopsin mutations page,PTM:Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.,similarity:Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.,tissue specificity:Rod shaped photoreceptor cells which mediates vision in dim light.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.